TBI history in relation to dementia variants

 
   Lead Investigator:    Jagan Pillai
   Institution      :    Cleveland Clinic
   E-Mail           :    pillaij@ccf.org
   Proposal ID      :    1476



   Proposal Description:
   Aim: To compare the clinical and neuropsychological characteristics among  participants exposed to TBI among neuropathology confirmed dementia types         Among subjects with autopsy confirmed diagnosis of primary Alzheimer???s         disease, dementia with lewy bodies, Frontotemporal dementia and vascular         dementia, we will determine the differences in the proportion of initial         clinical symptoms and the neuropsychological profile of subjects with and         without a TBI history.                                                           Chi squared tests will be used to compare the categorical variables with         respect to TBI history and initial clinical symptoms. After checking for         normality of data for continuous variables, ANOVA and Mann-Whitney's test will   be used to establish significant group differences as appropriate with respect   to TBI history.